Molecular basis of human CD22 function and therapeutic targeting

CD22 maintains a baseline level of B-cell inhibition to keep humoral immunity in check. As a B-cell-restricted antigen, CD22 is targeted in therapies against dysregulated B cells that cause autoimmune diseases and blood cancers. Here we report the crystal structure of human CD22 at 2.1 Å resolution,...

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Publicado no:Nat Commun
Main Authors: Ereño-Orbea, June, Sicard, Taylor, Cui, Hong, Mazhab-Jafari, Mohammad T., Benlekbir, Samir, Guarné, Alba, Rubinstein, John L., Julien, Jean-Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5624926/
https://ncbi.nlm.nih.gov/pubmed/28970495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00836-6
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