HSF1-dependent and -independent regulation of the mammalian in vivo heat shock response and its impairment in Huntington's disease mouse models

The heat shock response (HSR) is a mechanism to cope with proteotoxic stress by inducing the expression of molecular chaperones and other heat shock response genes. The HSR is evolutionarily well conserved and has been widely studied in bacteria, cell lines and lower eukaryotic model organisms. Howe...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Neueder, Andreas, Gipson, Theresa A., Batterton, Sophie, Lazell, Hayley J., Farshim, Pamela P., Paganetti, Paolo, Housman, David E., Bates, Gillian P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5624871/
https://ncbi.nlm.nih.gov/pubmed/28970536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12897-0
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