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The heat shock response, determined by QuantiGene multiplex, is impaired in HD mouse models and not caused by HSF1 reduction

Huntington’s disease (HD) is a devastating neurodegenerative disorder, caused by a CAG/polyglutamine repeat expansion, that results in the aggregation of the huntingtin protein, culminating in the deposition of inclusion bodies in HD patient brains. We have previously shown that the heat shock respo...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Gomez-Paredes, Casandra, Mason, Michael A., Taxy, Bridget A., Papadopoulou, Aikaterini S., Paganetti, Paolo, Bates, Gillian P.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8079691/
https://ncbi.nlm.nih.gov/pubmed/33907289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-88715-5
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