Cysteinyl leukotriene E(4) activates human group 2 innate lymphoid cells and enhances the effect of prostaglandin D(2) and epithelial cytokines

BACKGROUND: Group 2 innate lymphoid cells (ILC2s) are a potential innate source of type 2 cytokines in the pathogenesis of allergic conditions. Epithelial cytokines (IL-33, IL-25, and thymic stromal lymphopoietin [TSLP]) and mast cell mediators (prostaglandin D(2) [PGD(2)]) are critical activators o...

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Bibliographische Detailangaben
Veröffentlicht in:J Allergy Clin Immunol
Hauptverfasser: Salimi, Maryam, Stöger, Linda, Liu, Wei, Go, Simei, Pavord, Ian, Klenerman, Paul, Ogg, Graham, Xue, Luzheng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mosby 2017
Schlagworte:
Mechanisms of Allergy/Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5624780/
https://ncbi.nlm.nih.gov/pubmed/28115217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2016.12.958
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