Prostaglandin D(2) and leukotriene E(4) synergize to stimulate diverse T(H)2 functions and T(H)2 cell/neutrophil crosstalk

BACKGROUND: Prostaglandin D(2) (PGD(2)) and cysteinyl leukotrienes (cysLTs) are lipid mediators derived from mast cells, which activate T(H)2 cells. The combination of PGD(2) and cysLTs (notably cysteinyl leukotriene E(4) [LTE(4)]) enhances T(H)2 cytokine production. However, the synergistic interac...

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Bibliografiska uppgifter
I publikationen:J Allergy Clin Immunol
Huvudupphovsmän: Xue, Luzheng, Fergusson, Joannah, Salimi, Maryam, Panse, Isabel, Ussher, James E., Hegazy, Ahmed N., Vinall, Shân L., Jackson, David G., Hunter, Michael G., Pettipher, Roy, Ogg, Graham, Klenerman, Paul
Materialtyp: Artigo
Språk:Inglês
Publicerad: Mosby 2015
Ämnen:
Mechanisms of Allergy and Clinical Immunology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4418751/
https://ncbi.nlm.nih.gov/pubmed/25441644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2014.09.006
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