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Role of Topotecan in Non-Small Cell Lung Cancer: A Review of Literature
Topotecan (TPT), a chemotherapeutic agent, is a topoisomerase-I inhibitor. Topoisomerase-I is a nuclear enzyme that relieves torsion strain in DNA by opening single strand breaks which helps in DNA replication. TPT inhibits this enzyme, thus preventing DNA replication and causes cell death. TPT has...
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| 發表在: | World J Oncol |
|---|---|
| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Elmer Press
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5624667/ https://ncbi.nlm.nih.gov/pubmed/28983343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14740/wjon950e |
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