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Role of Topotecan in Non-Small Cell Lung Cancer: A Review of Literature
Topotecan (TPT), a chemotherapeutic agent, is a topoisomerase-I inhibitor. Topoisomerase-I is a nuclear enzyme that relieves torsion strain in DNA by opening single strand breaks which helps in DNA replication. TPT inhibits this enzyme, thus preventing DNA replication and causes cell death. TPT has...
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Publicado no: | World J Oncol |
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Main Authors: | , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Elmer Press
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5624667/ https://ncbi.nlm.nih.gov/pubmed/28983343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14740/wjon950e |
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