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Role of Topotecan in Non-Small Cell Lung Cancer: A Review of Literature

Topotecan (TPT), a chemotherapeutic agent, is a topoisomerase-I inhibitor. Topoisomerase-I is a nuclear enzyme that relieves torsion strain in DNA by opening single strand breaks which helps in DNA replication. TPT inhibits this enzyme, thus preventing DNA replication and causes cell death. TPT has...

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Detalhes bibliográficos
Publicado no:World J Oncol
Main Authors: Vennepureddy, Adarsh, Atallah, Jean-Paul, Terjanian, Terenig
Formato: Artigo
Idioma:Inglês
Publicado em: Elmer Press 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5624667/
https://ncbi.nlm.nih.gov/pubmed/28983343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14740/wjon950e
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