MUC5AC and a Glycosylated Variant of MUC5B Alter Mucin Composition in Children With Acute Asthma

BACKGROUND: Diffuse airway mucus obstruction is an important feature of severe and fatal asthma. MUC5AC and MUC5B are the principal gel-forming mucins found in airway mucus. The mucin composition of airway mucus likely affects its functional properties. METHODS: We quantified the principal airway mu...

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Bibliographische Detailangaben
Veröffentlicht in:Chest
Hauptverfasser: Welsh, Kathryn G., Rousseau, Karine, Fisher, Gemma, Bonser, Luke R., Bradding, Peter, Brightling, Chris E., Thornton, David J., Gaillard, Erol A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American College of Chest Physicians 2017
Schlagworte:
Critical Care
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5624091/
https://ncbi.nlm.nih.gov/pubmed/28716644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chest.2017.07.001
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