PRAS40 promotes NF-κB transcriptional activity through association with p65

PRAS40 has been shown to have a crucial role in the repression of mammalian target of rapamycin (mTOR). Nonetheless, PRAS40 appears to have an oncogenic function in cancer cells. Whether PRAS40 mediates signaling independent of mTOR inhibition in cancer cells remains elusive. Here PRAS40 overexpress...

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Foilsithe in:Oncogenesis
Main Authors: Zhu, G, Qi, Q, Havel, J J, Li, Z, Du, Y, Zhang, X, Fu, H
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2017
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Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5623906/
https://ncbi.nlm.nih.gov/pubmed/28945219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2017.80
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