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DJ-1 Inhibits α-Synuclein Aggregation by Regulating Chaperone-Mediated Autophagy
α-Synuclein misfolding and aggregation play an important role in the pathogenesis of Parkinson’s disease (PD). Loss of function and mutation of the PARK7/DJ-1 gene cause early-onset familial PD. DJ-1 can inhibit α-synuclein aggregation, and may function at an early step in the aggregation process. S...
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| 出版年: | Front Aging Neurosci |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Frontiers Media S.A.
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5623690/ https://ncbi.nlm.nih.gov/pubmed/29021755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2017.00308 |
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