DJ-1 Inhibits α-Synuclein Aggregation by Regulating Chaperone-Mediated Autophagy

α-Synuclein misfolding and aggregation play an important role in the pathogenesis of Parkinson’s disease (PD). Loss of function and mutation of the PARK7/DJ-1 gene cause early-onset familial PD. DJ-1 can inhibit α-synuclein aggregation, and may function at an early step in the aggregation process. S...

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Vydáno v:Front Aging Neurosci
Hlavní autoři: Xu, Chuan-Ying, Kang, Wen-Yan, Chen, Yi-Meng, Jiang, Tian-Fang, Zhang, Jia, Zhang, Li-Na, Ding, Jian-Qing, Liu, Jun, Chen, Sheng-Di
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2017
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5623690/
https://ncbi.nlm.nih.gov/pubmed/29021755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2017.00308
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