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LMO2 is required for TAL1 DNA binding activity and initiation of definitive haematopoiesis at the haemangioblast stage
LMO2 is a bridging factor within a DNA binding complex and is required for definitive haematopoiesis to occur. The developmental stage of the block in haematopoietic specification is not known. We show that Lmo2(−/−) mouse embryonic stem cells differentiated to Flk-1(+) haemangioblasts, but less eff...
Gespeichert in:
| Veröffentlicht in: | Nucleic Acids Res |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5622341/ https://ncbi.nlm.nih.gov/pubmed/28973433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx573 |
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