Adjuvant-Mediated Epitope Specificity and Enhanced Neutralizing Activity of Antibodies Targeting Dengue Virus Envelope Protein

The heat-labile toxins (LT) produced by enterotoxigenic Escherichia coli display adjuvant effects to coadministered antigens, leading to enhanced production of serum antibodies. Despite extensive knowledge of the adjuvant properties of LT derivatives, including in vitro-generated non-toxic mutant fo...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Maeda, Denicar Lina Nascimento Fabris, Batista, Milene Tavares, Pereira, Lennon Ramos, de Jesus Cintra, Mariana, Amorim, Jaime Henrique, Mathias-Santos, Camila, Pereira, Sara Araújo, Boscardin, Silvia Beatriz, Silva, Sandriana dos Ramos, Faquim-Mauro, Eliana L., Silveira, Vanessa Barbosa, Oliveira, Danielle Bruna Leal, Johnston, Stephen Albert, Ferreira, Luís Carlos de Souza, Rodrigues, Juliana Falcão
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5622152/
https://ncbi.nlm.nih.gov/pubmed/28993770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01175
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