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How Hsp90 And Cdc37 lubricate kinase molecular switches
The Hsp90/Cdc37 chaperone system interacts with and supports 60% of the human kinome. Not only are Hsp90 and Cdc37 generally required for initial folding, but many kinases rely on the Hsp90/Cdc37 throughout their lifetimes. A large fraction of these “client” kinases are key oncoproteins, and their i...
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| Pubblicato in: | Trends Biochem Sci |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5621984/ https://ncbi.nlm.nih.gov/pubmed/28784328 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2017.07.002 |
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