A TCRα framework–centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions

Selection of biased T cell receptor (TCR) repertoires across individuals is seen in both infectious diseases and autoimmunity, but the underlying molecular basis leading to these shared repertoires remains unclear. Celiac disease (CD) occurs primarily in HLA-DQ2.5(+) individuals and is characterized...

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Bibliografski detalji
Izdano u:JCI Insight
Glavni autori: Gunnarsen, Kristin Støen, Høydahl, Lene Støkken, Risnes, Louise Fremgaard, Dahal-Koirala, Shiva, Neumann, Ralf Stefan, Bergseng, Elin, Frigstad, Terje, Frick, Rahel, du Pré, M. Fleur, Dalhus, Bjørn, Lundin, Knut E.A., Qiao, Shuo-Wang, Sollid, Ludvig M., Sandlie, Inger, Løset, Geir Åge
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2017
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5621900/
https://ncbi.nlm.nih.gov/pubmed/28878121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.95193
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