Tead1 is required for maintaining adult cardiomyocyte function, and its loss results in lethal dilated cardiomyopathy

Heart disease remains the leading cause of death worldwide, highlighting a pressing need to identify novel regulators of cardiomyocyte (CM) function that could be therapeutically targeted. The mammalian Hippo/Tead pathway is critical in embryonic cardiac development and perinatal CM proliferation. H...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Liu, Ruya, Lee, Jeongkyung, Kim, Byung S., Wang, Qiongling, Buxton, Samuel K., Balasubramanyam, Nikhil, Kim, Jean J., Dong, Jianrong, Zhang, Aijun, Li, Shumin, Gupte, Anisha A., Hamilton, Dale J., Martin, James F., Rodney, George G., Coarfa, Cristian, Wehrens, Xander H.T., Yechoor, Vijay K., Moulik, Mousumi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5621883/
https://ncbi.nlm.nih.gov/pubmed/28878117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.93343
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