Somatic HLA mutations expose the role of class I–mediated autoimmunity in aplastic anemia and its clonal complications

Acquired aplastic anemia (aAA) is an acquired deficiency of early hematopoietic cells, characterized by inadequate blood production, and a predisposition to myelodysplastic syndrome (MDS) and leukemia. Although its exact pathogenesis is unknown, aAA is thought to be driven by human leukocyte antigen...

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Bibliografische gegevens
Gepubliceerd in:Blood Adv
Hoofdauteurs: Babushok, Daria V., Duke, Jamie L., Xie, Hongbo M., Stanley, Natasha, Atienza, Jamie, Perdigones, Nieves, Nicholas, Peter, Ferriola, Deborah, Li, Yimei, Huang, Hugh, Ye, Wenda, Morrissette, Jennifer J. D., Kearns, Jane, Porter, David L., Podsakoff, Gregory M., Eisenlohr, Laurence C., Biegel, Jaclyn A., Chou, Stella T., Monos, Dimitrios S., Bessler, Monica, Olson, Timothy S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2017
Onderwerpen:
Hematopoiesis and Stem Cells
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5621748/
https://ncbi.nlm.nih.gov/pubmed/28971166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017010918
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