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The DNA damage checkpoint eliminates mouse oocytes with chromosome synapsis failure
Pairing and synapsis of homologous chromosomes during meiosis is crucial for producing genetically normal gametes, and is dependent upon repair of SPO11-induced double stranded breaks (DSBs) by homologous recombination. To prevent transmission of genetic defects, diverse organisms have evolved mecha...
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| Publicado en: | Mol Cell |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5621520/ https://ncbi.nlm.nih.gov/pubmed/28844861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.07.027 |
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