Peptide microarray profiling identifies phospholipase C gamma 1 (PLC-γ1) as a potential target for t(8;21) AML

The t(8;21) (q22;q22) chromosomal translocation is one of the most frequent genetic alterations in acute myeloid leukemia (AML) which has a need for improved therapeutic strategies. We found PLC-γ1 as one of the highest phosphorylated peptides in t(8;21) AML samples compared to NBM or CN-AML in our...

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Udgivet i:Oncotarget
Main Authors: Mahmud, Hasan, Scherpen, Frank J.G., de Boer, Tiny Meeuwsen, Lourens, Harm-Jan, Schoenherr, Caroline, Eder, Matthias, Scherr, Michaela, Guryev, Victor, De Bont, Eveline S.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5620177/
https://ncbi.nlm.nih.gov/pubmed/28978037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18631
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