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General Anesthetics Regulate Autophagy via Modulating the Inositol 1,4,5-Trisphosphate Receptor: Implications for Dual Effects of Cytoprotection and Cytotoxicity
General anesthetics are both neuroprotective and neurotoxic with unclear mechanisms. General anesthetics may control cell survival via their effects on autophagy by activation of type 1 inositol triphosphate receptor (InsP(3)R-1). DT40 or SH-SY5Y cells with only or over 99% expression of InsP(3)R-1...
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| Foilsithe in: | Sci Rep |
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| Main Authors: | , , , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Nature Publishing Group UK
2017
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5620053/ https://ncbi.nlm.nih.gov/pubmed/28959036 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11607-0 |
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