Heme Oxygenase Induction Suppresses Hepatic Hepcidin and Rescues Ferroportin and Ferritin Expression in Obese Mice

Hepcidin, a phase II reactant secreted by hepatocytes, regulates cellular iron levels by increasing internalization of ferroportin-a transmembrane protein facilitating egress of cellular iron. Chronic low-grade inflammatory states, such as obesity, have been shown to increase oxidative stress and en...

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Bibliographic Details
Published in:J Nutr Metab
Main Authors: Puri, Nitin, Arefiev, Yevgeniy, Chao, Robert, Sacerdoti, David, Chaudry, Hibba, Nichols, Alexandra, Srikanthan, Krithika, Nawab, Athar, Sharma, Dana, Lakhani, Vishal Hari, Klug, Rebecca, Sodhi, Komal, Peterson, Stephen J.
Format: Artigo
Language:Inglês
Published: Hindawi 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5618758/
https://ncbi.nlm.nih.gov/pubmed/29062571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/4964571
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