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Mitochondrial Liver Toxicity of Valproic Acid and Its Acid Derivatives Is Related to Inhibition of α-Lipoamide Dehydrogenase

The liver toxicity of valproic acid (VPA) is an established side effect of this widely used antiepileptic drug, which is extremely problematic for patients with metabolic epilepsy and particularly epilepsy due to mitochondrial dysfunction. In the present report, we investigated the reason for liver...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Kudin, Alexei P., Mawasi, Hafiz, Eisenkraft, Arik, Elger, Christian E., Bialer, Meir, Kunz, Wolfram S.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5618561/
https://ncbi.nlm.nih.gov/pubmed/28878165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18091912
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