Non-Targeted Metabolomics Analysis of Golden Retriever Muscular Dystrophy-Affected Muscles Reveals Alterations in Arginine and Proline Metabolism, and Elevations in Glutamic and Oleic Acid In Vivo

Background: Like Duchenne muscular dystrophy (DMD), the Golden Retriever Muscular Dystrophy (GRMD) dog model of DMD is characterized by muscle necrosis, progressive paralysis, and pseudohypertrophy in specific skeletal muscles. This severe GRMD phenotype includes moderate atrophy of the biceps femor...

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Udgivet i:Metabolites
Main Authors: Abdullah, Muhammad, Kornegay, Joe N., Honcoop, Aubree, Parry, Traci L., Balog-Alvarez, Cynthia J., O’Neal, Sara K., Bain, James R., Muehlbauer, Michael J., Newgard, Christopher B., Patterson, Cam, Willis, Monte S.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5618323/
https://ncbi.nlm.nih.gov/pubmed/28758940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/metabo7030038
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