Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model

Immune checkpoint inhibitors and adoptive cell transfer (ACT) of autologous tumor-infiltrating T cells have shown durable responses in patients with melanoma. To study ACT and immunotherapies in a humanized model, we have developed PDXv2.0 — a melanoma PDX model where tumor cells and tumor-infiltrat...

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Publicado no:Nat Commun
Main Authors: Jespersen, Henrik, Lindberg, Mattias F., Donia, Marco, Söderberg, Elin M. V., Andersen, Rikke, Keller, Ulrich, Ny, Lars, Svane, Inge Marie, Nilsson, Lisa M., Nilsson, Jonas A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617838/
https://ncbi.nlm.nih.gov/pubmed/28955032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00786-z
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