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miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity

Autoreactive CD4 T cells that differentiate into pathogenic Th17 cells can trigger autoimmune diseases. Therefore, investigating the regulatory network that modulates Th17 differentiation may yield important therapeutic insights. miR-146a has emerged as a critical modulator of immune reactions, but...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Li, Bo, Wang, Xi, Choi, In Young, Wang, Yu-Chen, Liu, Siyuan, Pham, Alexander T., Moon, Heesung, Smith, Drake J., Rao, Dinesh S., Boldin, Mark P., Yang, Lili
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617680/
https://ncbi.nlm.nih.gov/pubmed/28872459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI94012
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