Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses

Foxp3(+) regulatory T (Treg) cells maintain immune homeostasis by limiting different types of inflammatory responses. Here, we report that miR-146a, one of the miRNAs prevalently expressed in Treg cells, is critical for their suppressor function. The deficiency of miR-146a in Treg cells resulted in...

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Hoofdauteurs: Lu, Li-Fan, Boldin, Mark P., Chaudhry, Ashutosh, Lin, Ling-Li, Taganov, Konstantin D., Hanada, Toshikatsu, Yoshimura, Akihiko, Baltimore, David, Rudensky, Alexander Y.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049116/
https://ncbi.nlm.nih.gov/pubmed/20850013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.08.012
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