ER-associated degradation is required for vasopressin prohormone processing and systemic water homeostasis

Peptide hormones are crucial regulators of many aspects of human physiology. Mutations that alter these signaling peptides are associated with physiological imbalances that underlie diseases. However, the conformational maturation of peptide hormone precursors (prohormones) in the ER remains largely...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Shi, Guojun, Somlo, Diane R.M., Kim, Geun Hyang, Prescianotto-Baschong, Cristina, Sun, Shengyi, Beuret, Nicole, Long, Qiaoming, Rutishauser, Jonas, Arvan, Peter, Spiess, Martin, Qi, Ling
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617659/
https://ncbi.nlm.nih.gov/pubmed/28920920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI94771
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