A functional variant in GREM1 confers risk for colorectal cancer by disrupting a hsa-miR-185-3p binding site

The transforming growth factor beta (TGF-β) pathway has been implicated in carcinogenesis of intestinal canal. Except for common variants indentified by genome-wide association studies, variants with lower frequency can also explain a part of the disease heritability, especially those in gene regula...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Li, Jiaoyuan, Liu, Hui, Zou, Li, Ke, Juntao, Zhang, Yi, Zhu, Ying, Yang, Yang, Gong, Yajie, Tian, Jianbo, Zou, Danyi, Peng, Xiating, Gong, Jing, Zhong, Rong, Huang, Kun, Chang, Jiang, Miao, Xiaoping
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617425/
https://ncbi.nlm.nih.gov/pubmed/28977865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18095
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