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The IGF-1R/AKT pathway determines cell fate in response to p53
p53 that is activated in response to DNA-damaging stress can induce apoptosis or either transient or permanent cell cycle arrests. Apoptosis and permanent cell cycle arrest (senescence) are bona-fide tumor suppressor mechanisms through which p53 inhibits cancer cell survival. In contrast, transient...
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| Veröffentlicht in: | Transl Cancer Res |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5617345/ https://ncbi.nlm.nih.gov/pubmed/28966916 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/tcr.2016.09.16 |
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