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Stachel-independent modulation of GPR56/ADGRG1 signaling by synthetic ligands directed to its extracellular region
Adhesion G protein-coupled receptors (aGPCRs) play critical roles in diverse biological processes, including neurodevelopment and cancer progression. aGPCRs are characterized by large and diverse extracellular regions (ECRs) that are autoproteolytically cleaved from their membrane-embedded signaling...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5617296/ https://ncbi.nlm.nih.gov/pubmed/28874577 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708810114 |
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