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Binding mechanism and dynamic conformational change of C subunit of PKA with different pathways
The catalytic subunit of PKA (PKAc) exhibits three major conformational states (open, intermediate, and closed) during the biocatalysis process. Both ATP and substrate/inhibitor can effectively induce the conformational changes of PKAc from open to closed states. Aiming to explore the mechanism of t...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5617255/ https://ncbi.nlm.nih.gov/pubmed/28855336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1702599114 |
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