PD-1 and CTLA-4 up regulation on donor T cells is insufficient to prevent GvHD in allo-HSCT recipients

The expression of checkpoint blockade molecules PD-1, PD-L1, CTLA-4, and foxp3+CD25+CD4+ T cells (Tregs) regulate donor T cell activation and graft-vs-host disease (GvHD) in allogeneic hematopoietic stem cell transplant (allo-HSCT). Detailed kinetics of PD-1-, CTLA-4-, and PD-L1 expression on donor...

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Publicado no:PLoS One
Main Authors: Hossain, Mohammad S., Kunter, Ghada M., El-Najjar, Vicky F., Jaye, David L., Al-Kadhimi, Zaid, Taofeek, Owonikoko K., Li, Jian-Ming, Waller, Edmund K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617147/
https://ncbi.nlm.nih.gov/pubmed/28953925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0184254
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