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Blocking ERK1/2 signaling impairs TGF-β1 tumor promoting function but enhances its tumor suppressing role in intrahepatic cholangiocarcinoma cells
BACKGROUND: Transforming growth factor-β (TGF-β) plays a paradoxical role in cancer: it suppresses proliferation at early stages but promotes metastasis at late stages. This cytokine is upregulated in cholangiocarcinoma and is implicated in cholangiocarcinoma invasion and metastasis. Here we investi...
Shranjeno v:
| izdano v: | Cancer Cell Int |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
BioMed Central
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5615482/ https://ncbi.nlm.nih.gov/pubmed/28959141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-017-0454-2 |
| Oznake: |
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