Blocking ERK1/2 signaling impairs TGF-β1 tumor promoting function but enhances its tumor suppressing role in intrahepatic cholangiocarcinoma cells

BACKGROUND: Transforming growth factor-β (TGF-β) plays a paradoxical role in cancer: it suppresses proliferation at early stages but promotes metastasis at late stages. This cytokine is upregulated in cholangiocarcinoma and is implicated in cholangiocarcinoma invasion and metastasis. Here we investi...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cancer Cell Int
Egile Nagusiak: Sritananuwat, Phaijit, Sueangoen, Natthaporn, Thummarati, Parichut, Islam, Kittiya, Suthiphongchai, Tuangporn
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2017
Gaiak:
Primary Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5615482/
https://ncbi.nlm.nih.gov/pubmed/28959141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-017-0454-2
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