Blocking ERK1/2 signaling impairs TGF-β1 tumor promoting function but enhances its tumor suppressing role in intrahepatic cholangiocarcinoma cells

BACKGROUND: Transforming growth factor-β (TGF-β) plays a paradoxical role in cancer: it suppresses proliferation at early stages but promotes metastasis at late stages. This cytokine is upregulated in cholangiocarcinoma and is implicated in cholangiocarcinoma invasion and metastasis. Here we investi...

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Detalhes bibliográficos
Publicado no:Cancer Cell Int
Main Authors: Sritananuwat, Phaijit, Sueangoen, Natthaporn, Thummarati, Parichut, Islam, Kittiya, Suthiphongchai, Tuangporn
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Primary Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5615482/
https://ncbi.nlm.nih.gov/pubmed/28959141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-017-0454-2
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