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PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila
The mitochondrial unfolded protein response (UPR(mt)) has been associated with long lifespan across metazoans. In Caenorhabditis elegans, mild developmental mitochondrial stress activates UPR(mt) reporters and extends lifespan. We show that similar developmental stress is necessary and sufficient to...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5614561/ https://ncbi.nlm.nih.gov/pubmed/28891792 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.26952 |
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