The RAB2B-GARIL5 complex promotes cytosolic DNA-induced innate immune responses

Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that induces the IFN antiviral response. However, the regulatory mechanisms that mediate cGAS-triggered signaling have not been fully explored. Here, we show the involvement of a small GTPase RAB2B and its effector protein Golgi-associated RAB...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Takahama, Michihiro, Fukuda, Mitsunori, Ohbayashi, Norihiko, Kozaki, Tatsuya, Misawa, Takuma, Okamoto, Toru, Matsuura, Yoshiharu, Akira, Shizuo, Saitoh, Tatsuya
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5614515/
https://ncbi.nlm.nih.gov/pubmed/28930687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.08.085
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