Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure

Drug resistance is a major challenge in cancer therapy. The generation of resistant sublines in vitro is necessary for discovering novel mechanisms to overcome this challenge. Here, a 2-step dose-escalation method for establishing dual-resistance to an epidermal growth factor receptor (EGFR)-tyrosin...

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Bibliographic Details
Published in:J Vis Exp
Main Authors: Yamaoka, Toshimitsu, Ohba, Motoi, Arata, Satoru, Ohmori, Tohru
Format: Artigo
Language:Inglês
Published: MyJove Corporation 2017
Subjects:
Cancer Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5614313/
https://ncbi.nlm.nih.gov/pubmed/28829429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/55967
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