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Hypoxia-Activated Alkylating Agents in BRCA1-Mutant Ovarian Serous Carcinoma
Breast cancer 1 antigen (BRCA 1) and breast cancer 2 antigen (BRCA2) genes play a significant role in deoxyribonucleic acid (DNA) repair by means of interstrand crosslink repair, and deleterious germline mutations of these are responsible for most hereditary breast and ovarian cancers. Therapeutic s...
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| Udgivet i: | Cureus |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cureus
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5613928/ https://ncbi.nlm.nih.gov/pubmed/28959512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7759/cureus.1517 |
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