Functional significance of active site residues in the enzymatic component of the Clostridium difficile binary toxin

Clostridium difficile binary toxin (CDT) is an ADP-ribosyltransferase which is linked to enhanced pathogenesis of C. difficile strains. CDT has dual function: domain a (CDTa) catalyses the ADP-ribosylation of actin (enzymatic component), whereas domain b (CDTb) transports CDTa into the cytosol (tran...

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Publicat a:Biochem Biophys Rep
Autors principals: Davies, Abigail H., McGlashan, Joanna, Posner, Mareike G., Roberts, April K., Shone, Clifford C., Acharya, K. Ravi
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5613739/
https://ncbi.nlm.nih.gov/pubmed/28955942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2016.08.011
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