Transforming growth factor-β-induced CUX1 isoforms are associated with fibrosis in systemic sclerosis lung fibroblasts

In the enhancer region of the human type I collagen alpha 2 (COL1A2) gene, we identified cis-elements for the transcription factor CUX1. However, the role of CUX1 in fibrosis remains unclear. Here we investigated the role of CUX1 in the regulation of COL1 expression and delineated the mechanisms und...

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Detalhes bibliográficos
Publicado no:Biochem Biophys Rep
Principais autores: Ikeda, Tetsurou, Fragiadaki, Maria, Shi-wen, Xu, Ponticos, Markella, Khan, Korsa, Denton, Christopher, Garcia, Patricia, Bou-Gharios, George, Yamakawa, Akio, Morimoto, Chikao, Abraham, David
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5613511/
https://ncbi.nlm.nih.gov/pubmed/28955913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2016.06.022
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