Estradiol impairs the antiproliferative and proapoptotic effect of Zoledronic acid in hormone sensitive breast cancer cells in vitro

BACKGROUND: Zoledronic acid (ZA) has antiresorptive effects and protects from bone metastasis in women with early breast cancer. In addition, in postmenopausal women with endocrine responsive breast cancer ZA prolongs DFS. The exact mechanism is still unclear. We have therefore investigated the effe...

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Udgivet i:PLoS One
Main Authors: Gschwantler-Kaulich, Daphne, Weingartshofer, Sigrid, Grunt, Thomas W., Mairhofer, Mario, Tan, Yen, Gamper, Jutta, Singer, Christian F.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5612728/
https://ncbi.nlm.nih.gov/pubmed/28945801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0185566
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