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PTPN22 regulates NLRP3-mediated IL1B secretion in an autophagy-dependent manner
A variant within the gene locus encoding PTPN22 (protein tyrosine phosphatase, non-receptor type 22) emerged as an important risk factor for auto-inflammatory disorders, including rheumatoid arthritis, systemic lupus erythematosus and type 1 diabetes, but at the same time protects from Crohn disease...
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| Veröffentlicht in: | Autophagy |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5612532/ https://ncbi.nlm.nih.gov/pubmed/28786745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1341453 |
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