The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex

Sharpin, a multifunctional adaptor protein, regulates several signalling pathways. For example, Sharpin enhances signal-induced NF-κB signalling as part of the linear ubiquitin assembly complex (LUBAC) and inhibits integrins, the T cell receptor, caspase 1 and PTEN. However, despite recent insights...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Khan, Meraj H., Salomaa, Siiri I., Jacquemet, Guillaume, Butt, Umar, Miihkinen, Mitro, Deguchi, Takahiro, Kremneva, Elena, Lappalainen, Pekka, Humphries, Martin J., Pouwels, Jeroen
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5612173/
https://ncbi.nlm.nih.gov/pubmed/28775156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.200329
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