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Linchpin DNA-binding residues serve as go/no-go controls in the replication factor C-catalyzed clamp-loading mechanism
DNA polymerases depend on circular sliding clamps for processive replication. Clamps must be loaded onto primer–template DNA (ptDNA) by clamp loaders that open and close clamps around ptDNA in an ATP-fueled reaction. All clamp loaders share a core structure in which five subunits form a spiral chamb...
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| 出版年: | J Biol Chem |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5612119/ https://ncbi.nlm.nih.gov/pubmed/28808059 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.798702 |
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