Reconstructed ancestral enzymes reveal that negative selection drove the evolution of substrate specificity in ADP-dependent kinases

One central goal in molecular evolution is to pinpoint the mechanisms and evolutionary forces that cause an enzyme to change its substrate specificity; however, these processes remain largely unexplored. Using the glycolytic ADP-dependent kinases of archaea, including the orders Thermococcales, Meth...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Castro-Fernandez, Víctor, Herrera-Morande, Alejandra, Zamora, Ricardo, Merino, Felipe, Gonzalez-Ordenes, Felipe, Padilla-Salinas, Felipe, Pereira, Humberto M., Brandão-Neto, Jose, Garratt, Richard C., Guixe, Victoria
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5612095/
https://ncbi.nlm.nih.gov/pubmed/28726643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.790865
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