Loss of Cln5 causes altered neurogenesis in a mouse model of a childhood neurodegenerative disorder

Neural stem/progenitor cells (NPCs) generate new neurons in the brain throughout an individual's lifetime in an intricate process called neurogenesis. Neurogenic alterations are a common feature of several adult-onset neurodegenerative diseases. The neuronal ceroid lipofuscinoses (NCLs) are the...

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Foilsithe in:Dis Model Mech
Main Authors: Savchenko, Ekaterina, Singh, Yajuvinder, Konttinen, Henna, Lejavova, Katarina, Mediavilla Santos, Laura, Grubman, Alexandra, Kärkkäinen, Virve, Keksa-Goldsteine, Velta, Naumenko, Nikolay, Tavi, Pasi, White, Anthony R., Malm, Tarja, Koistinaho, Jari, Kanninen, Katja M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Company of Biologists Ltd 2017
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5611964/
https://ncbi.nlm.nih.gov/pubmed/28733362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.029165
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