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Hsp90 sensitivity to ADP reveals hidden regulation mechanisms
The ATPase cycle of the Hsp90 molecular chaperone is essential for maintaining the stability of numerous client proteins. Extensive analysis has focused on ATP-driven conformational changes of Hsp90, however, little is known about how Hsp90 operates under physiological nucleotide conditions in which...
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| Veröffentlicht in: | J Mol Biol |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5610941/ https://ncbi.nlm.nih.gov/pubmed/28822683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2017.08.005 |
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