Induction of Mkp-1 and Nuclear Translocation of Nrf2 by Limonoids from Khaya grandifoliola C.DC Protect L-02 Hepatocytes against Acetaminophen-Induced Hepatotoxicity

Drug-induced liver injury (DILI) is a major clinical problem where natural compounds hold promise for its abrogation. Khaya grandifoliola (Meliaceae) is used in Cameroonian traditional medicine for the treatment of liver related diseases and has been studied for its hepatoprotective properties. Till...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Kouam, Arnaud F., Yuan, Fei, Njayou, Frédéric N., He, Hongtao, Tsayem, Roméo F., Oladejo, Babayemi O., Song, Fuhang, Moundipa, Paul F., Gao, George F.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610691/
https://ncbi.nlm.nih.gov/pubmed/28974930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00653
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