Induction of Mkp-1 and Nuclear Translocation of Nrf2 by Limonoids from Khaya grandifoliola C.DC Protect L-02 Hepatocytes against Acetaminophen-Induced Hepatotoxicity

Drug-induced liver injury (DILI) is a major clinical problem where natural compounds hold promise for its abrogation. Khaya grandifoliola (Meliaceae) is used in Cameroonian traditional medicine for the treatment of liver related diseases and has been studied for its hepatoprotective properties. Till...

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Опубликовано в: :Front Pharmacol
Главные авторы: Kouam, Arnaud F., Yuan, Fei, Njayou, Frédéric N., He, Hongtao, Tsayem, Roméo F., Oladejo, Babayemi O., Song, Fuhang, Moundipa, Paul F., Gao, George F.
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2017
Предметы:
Pharmacology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610691/
https://ncbi.nlm.nih.gov/pubmed/28974930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00653
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