A case of resistance to tyrosine kinase inhibitor therapy: small cell carcinoma transformation concomitant with plasma-genotyped T790M positivity

Although non-small-cell lung cancer patients with epidermal growth factor receptor (EGFR) mutations are responsive to EGFR-tyrosine kinase inhibitors, drug resistances are always inevitable. The secondary somatic EGFR threonine–methionine substitution at position 790 (T790M) mutation accounts for ∼5...

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Publicado en:Anticancer Drugs
Autores principales: Xu, Yanjun, Huang, Zhiyu, Gong, Lei, Fan, Yun
Formato: Artigo
Lenguaje:Inglês
Publicado: Lippincott Williams & Wilkins 2017
Materias:
Case Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610567/
https://ncbi.nlm.nih.gov/pubmed/28723866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CAD.0000000000000540
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